Epitalon 10 mg

Description

Epitalon (10mg) is a high-purity, synthetic tetrapeptide supplied as a lyophilized (freeze-dried) powder in a single sterile vial. This 10mg vial is intended exclusively for laboratory and scientific research purposes, such as in vitro cell culture studies, animal models, biochemical assays, or investigations into cellular aging, telomere biology, and gerontology. Epitalon (also known as Epithalon or Epithalone) is not approved for human consumption, therapeutic use, medical treatment, dietary supplementation, or veterinary applications by any regulatory agency (e.g., FDA, EMA). All handling must be performed by qualified researchers following strict laboratory and biosafety protocols.

Key Specifications

• Chemical Name: Ala-Glu-Asp-Gly (AEDG)
• Molecular Formula: C₁₄H₂₂N₄O₉
• Molecular Weight: 390.35 g/mol
• Amino Acid Sequence: Ala-Glu-Asp-Gly (often written as AEDG)
• CAS Number: 307297-39-8
• Synonyms: Epithalon, Epithalone, Epitalon, Pineal tetrapeptide
• Purity: ≥98–99% (verified by HPLC; third-party Certificate of Analysis recommended)
• Appearance: White to off-white lyophilized powder
• Form: Single 10mg vial (requires reconstitution with bacteriostatic water, sterile water, or appropriate buffer for research use)
• Storage: Lyophilized — store at -20°C or colder, protected from light and moisture for long-term stability. After reconstitution — refrigerate at 2–8°C and use promptly (stability typically days to weeks depending on buffer and conditions). Avoid repeated freeze-thaw cycles.

Research Background and Mechanism

Epitalon is a synthetic tetrapeptide modeled after the active components of epithalamin, a natural polypeptide extract from the bovine pineal gland. Developed primarily through research by Vladimir Khavinson and colleagues starting in the 1990s–2000s, Epitalon has been extensively studied in preclinical models (e.g., rodents, cell lines) for its potential geroprotective (anti-aging) properties.

The primary mechanism explored involves telomerase activation:

• Epitalon induces expression of telomerase components (e.g., hTERT mRNA) and increases telomerase enzyme activity in somatic cells.
• This leads to telomere elongation (reported increases of up to ~33% in some human fibroblast studies) and helps counteract telomere shortening associated with cellular senescence and aging.
• Additional effects in models include restoration of melatonin rhythms, modulation of neuroendocrine function, antioxidant activity, and potential inhibition of spontaneous tumor development.

Preclinical studies (in vitro human cells, rodents) have demonstrated:

• Telomere lengthening via telomerase upregulation or alternative lengthening of telomeres (ALT) pathways.
• Improved circadian regulation and pineal gland function.
• Enhanced cellular health, reduced oxidative stress, and extended lifespan in aging models.

Recent 2025 research continues to explore its role in oocyte maturation, blastocyst quality, and broader anti-aging mechanisms.

Potential Research Applications

In controlled laboratory settings, Epitalon is investigated for:

• Telomere biology, telomerase regulation, and cellular senescence models
• Gerontology and longevity mechanisms (e.g., pineal gland function, melatonin restoration)
• Neuroendocrine and circadian rhythm studies
• Antioxidant and cytoprotective effects in aging or stress models
• Potential influences on tumor suppression and immune-endocrine interactions

It exhibits high stability and bioavailability in experimental systems.

Important Notes

Epitalon remains unapproved for any human or clinical use. While preclinical data are promising, no large-scale human trials have led to regulatory approval for therapeutic applications. All products are sold strictly for research use only — not for diagnostic, therapeutic, personal consumption, or performance enhancement purposes. Researchers must use sterile reconstitution techniques (gentle swirling, avoid vigorous agitation), proper storage, and biosafety measures. Always verify purity and identity via independent lab analysis (COA) and comply with institutional guidelines.